aiims pg emqsCharacterstic Drug Toxicities
Revision List 

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Agranulocytosis

· Clozapine

Aplastic Anemia

· Chloramphenicol
· NSAIDs
· Benzene

Atropine-like Side Effects

· Tricyclics

Cardiotoxicity

· Doxorubicin
· Daunorubicin

Cartilage Damage in children

· Fluoroquinolones (Ciprofloxacin & Norfloxacin)

Cinchonism

· Quinidine

Coronary Steal Phenomenon

·  Dipyridamole

Corneal micro deposits

·  Amiodarone

Cough

· ACE Inhibitors

Diabetes Insipidus

· Lithium

Disulfiram-like effect

· Metronidazole
· Sulfonylureas (1st generation)

Extrapyramidal Side Effects

· Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)

Fanconi’s Syndrome

· Tetracycline

Fatal Hepatotoxicity (necrosis)

· Valproic Acid
· Halothane
· Acetaminophen

Gingival Hyperplasia

· Phenytoin

Gray Baby Syndrome

· Chloramphenicol

Gynecomastia

· Cimetidine
· Azoles
· Spironolactone
· Digitalis
· Estrogen & testosterone
· INH & ethionamide
· Clomiphine
· Phenytoin
· Reserpine & Methyldopa

Hand Foot Syndrome

·  5-Flurouracil (5-FU)

Hemolytic Anemia in G6PD-deficiency

· Sulfonamides
· Isoniazid
· Aspirin
· Ibuprofen
· Primaquine

Hemorrhagic Cystitis

· Cyclophosphamide
· Ifosamide  (Treat by Mesna & Acetylcysteine Bladder Wash)

Hepatitis

· Isoniazid

Hot Flashes, Flushing

· Niacin
· Tamoxifen
· Ca++ Channel Blockers

Hypertension: Postural

· Prazocin

Hypertension: Rebound

· Clonidine withdrawal

Increased intra cranial tension (­ ICT)

· Amiodarone
· Hypervitaminosis A
·  OCP’s
·  Tetracycline
·  Quinolones  

Induce CP450

· Barbiturates
· Phenytoin
· Carbamazepine
· Rifampin

Inhibit CP450

·  Cimetidine
·  Erythromycin
·  Ketoconazole
·  Isoniazid (INH) [remember CEKI]

Interstitial Nephritis

· Methicillin
· NSAIDs (except Aspirin)
· Furosemide
· Sulfonamides

Milk Alkali Syndrome

·  Calcium Carbonate (CaCo3)

Monday Disease

· Nitroglycerin Industrial exposure ® tolerance during week ® loss of tolerance during weekend ® headache, tach, dizziness upon re-exposure

Nephrotoxicity

· Cephaloridine
· Gentamycin
· Amphotericin

Orange Body Fluids

· Rifampin

Osteoporosis

· Heparin
· Corticosteroids

Pancreatitis

·  L-Asparginase
·  Glucocorticoids

Photosensitivity

· Lomefloxacin
· Pefloxacin

Positive Coombs’ Test

· Methyldopa

Pulmonary Fibrosis

· Bleomycin
· Amiodarone

Rabbit Syndrome (Perioral tremors)

·  Phenothiazines

Red Man Syndrome

· Vancomycin (rapid IV)

Severe HTN with Tyramine

· MAOIs

SLE- Drug Induced
[Anti Histone Antibody Characteristic of this]

· Chloropromazine
· Hydralazine
· Isoniazid
· Methyldopa
· Procainamide
· Quinidine [ remember CHIMP -Q]

Tardive Dyskinesia

· Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)

Tinnitus

· Aspirin
· Quinidine

Torsades de Pontis

· Terfanadine

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